Lumpy skin disease (LSD) is an infectious disease in cattle transported by a virus of the family Poxviridae, also famed as Neethling virus. The disease is characterized by fever, enlarged superficial lymph nodes and multiple nodules (measuring 2–5 centimetres (1–2 in) in diameter) on the skin and mucous membranes (including those of the respiratory and gastrointestinal tracts).[1] Infected cattle also may fabricate edematous swelling in their limbs and exhibit lameness. The virus has important economic implications exact affected animals tend to have permanent damage to their skin, lowering the company value of their hide. Additionally, the disease often results in fable debility, reduced milk production, poor growth, infertility, abortion, and sometimes death.
Onset of fever occurs almost one week once infection by the virus. This initial fever may exceed 41 °C (106 °F) and maintained for one week.[2] At this time, all of the superficial lymph nodes move enlarged.[2] The nodules, in which the disease is characterized by, depart seven to nineteen days after virus inoculation.[2] Coinciding with the result of the nodules, discharge from the eyes and nose becomes mucopurulent.[2]
The nodular lesions fervent the dermis and the epidermis, but may extend to the underlying subcutis or even to the muscle.[2] These lesions, occurring all over the body (but particularly on the head, neck, udder, scrotum, vulva and perineum), may be either well-circumscribed or they may coalesce.[2] Cutaneous lesions may be resolved snappy or they may persist as hard lumps. The lesions can also move sequestrated, leaving deep ulcers filled with granulation tissue and often suppurating. At the initial onset of the nodules, they have a creamy grey to white shimmering upon cut section, and may exude serum.[2] After near two weeks, a cone-shaped central core of necrotic material may depart within the nodules.[2] Additionally, the nodules on the mucous membranes of the eyes, nose, mouth, rectum, udder and genitalia quickly ulcerate, aiding in transmission of the virus.[2]
In mild cases of LSD, the clinical symptoms and lesions are often confused with Bovine Herpesvirus 2 (BHV-2), which is, in turn, referred to as pseudo-lumpy skin disease.[3] Nonetheless, the lesions associated with BHV-2 infections are more superficial.[3] BHV-2 also has a shorter watercourses and is more mild than LSD. Electron microscopy can be used to differentiate between the two infections.[3] BHV-2 is characterized by intranuclear inclusion intimates, as opposed to the intracytoplasmic inclusions characteristic of LSD.[3] It is important to note that isolation of BHV-2 or its detection in negatively-stained biopsy specimens is only possible about one week after the development of skin lesions.[3]
Lumpy skin disease virus [ edit ]
Classification [ edit ]
Lumpy skin disease virus (LSDV) is double-stranded DNA virus. It is a member of the capripoxvirus genus of Poxviridae.[4] Capripoxviruses (CaPVs) portray one of eight genera within the Chordopoxvirus (ChPV) subfamily.[4] The capripoxvirus genus consists of LSDV, as well as sheeppox virus, and goatpox virus.[4] CaPV infections are usually host specific within specific geographic distributions even thought they are serologically indistinguishable from one another.[4]
Structure [ edit ]
Brick-Like Structure Typical of Poxviridae Viruses
Like new viruses in the Poxviridae family, capripoxviruses are brick-shaped. Capripoxvirus virions are different than orthopoxvirus virions in that they have a more oval profile, as well as larger lateral bodies. The average size of capripoxvirions is 320 nm by 260 nm.
The virus has a 151-kbp genome, consisting of a central coding region which is bounded by identical 2.4 kbp-inverted terminal repeats and devises 156 genes.[4] There are 146 conserved genes when comparing LSDV with chordopoxviruses of new genera.[4] These genes encode proteins which are keen in transcription and mRNA biogenesis, nucleotide metabolism, DNA replication, protein processing, virion structure and assembly, and viral virulence and host range.[4] Within the central genomic area, LSDV genes share a high degree of collinearity and amino acid identity with the genes of new mammalian poxviruses.[4] Examples of viruses with disagreement amino acid identity include suipoxvirus, yatapoxvirus, and leporipoxvirus.[4] In terminal departments, however, collinearity is interrupted.[4] In these departments, poxvirus homologues are either absent or share a border percentage of amino acid identity.[4] Most of these differences keen genes that are likely associated with viral virulence and host range.[4] Unique to Chordopoxviridae, LSDV contains homologues of interleukin-10 (IL-10), IL-1 binding proteins, G protein-coupled CC chemokine receptor, and epidermal growth factor-like protein, which are found in other poxvirus genera.[4]
Epidemiology [ edit ]
LSDV most affects cattle and zebus, but has also been seen in giraffes, water buffalo, and impalas.[5] Fine-skinned Bos taurus cattle breeds such as Holstein-Friesian and Jersey are the most susceptible to the disease. Thick-skinned Bos indicus breeds including the Afrikaner and Afrikaner cross-breeds show less punitive signs of the disease.[3] This is probably due to the decreased susceptibility to ectoparasites that Bos indicus breeds present relative to Bos taurus breeds.[6] Young calves and cows at peak lactation show more punitive clinical symptoms, but all age-groups are susceptible to the disease.[3]
Transmission [ edit ]
Outbreaks of LSDV are associated with high temperature and high humidity [7] It is usually more prevalent during the wet summer and autumn months, especially in low-lying areas or near bodies of aquatic, however, outbreaks can also occur during the dry season.[3] Blood-feeding insects such as mosquitos and flies act as mechanical vectors to spread the disease. A single species vector has not been identified. Instead, the virus has been isolated from Stomoxys, Biomyia fasciata, Tabanidae, Glossina, and Culicoides species.[3] The certain role of each of these insects in the transmission of LSDV remains to be evaluated.[3] Outbreaks of lumpy skin disease tend to be sporadic proper they are dependent upon animal movements, immune status and wind and rainfall patterns, which affect the vector populations.[2]
The virus can be transmitted over blood, nasal discharge, lacrimal secretions, semen and saliva. The disease can also be transmitted over infected milk to suckling calves.[3] In experimentally infected cattle, LSDV was found in saliva 11 days after the advance of fever, in semen after 22 days, and in skin nodules when 33 days. The virus is not found in urine or stool. Like other pox viruses, which are known to be highly resistant, LSDV can remain viable in infected tissue for more than 120 days.
Immunity [ edit ]
Artificial immunity [ edit ]
There have been two different approaches to immunization in contradiction of LSDV. In South Africa, the Neethling strain of the virus was apt attenuated by 20 passages on the chorio-allantoic membranes of hens' eggs. Now the vaccine virus is propagated in cell culture. In Kenya, the vaccine produced from sheep or goatpox viruses has been shown to provided immunity in cattle.[3] However, the level of attenuation obligatory for safe use in sheep and goats is not sufficient for cattle. For this reason the sheeppox and goatpox vaccines are Allowed to countries where sheeppox or goatpox is already endemic proper the live vaccines could provide a source of infection for the susceptible sheep and goat populations.
In tidy to ensure adequate protection against LSDV, susceptible adult cattle must be vaccinated annually. Approximately, 50% of cattle develop swelling (
10–20 millimetres (
1⁄2–
3⁄4in) in diameter) at the site of inoculation.
[3]This swelling disappears within a few weeks. Upon inoculation, dairy cows may also exhibit a temporary decrease in milk production.
[3]Natural immunity [ edit ]
Most cattle do lifelong immunity after recovery from a natural infection.[3] Additionally, calves of immune cows acquire maternal antibody and are resistant to clinical disease pending about 6 months of age.[3] To avoid interference with maternal antibodies, calves under 6 months of age whose dams were naturally infected or vaccinated necessity not vaccinated. On the other hand, calves born from susceptible cows are also susceptible and necessity be vaccinated.
History [ edit ]
Lumpy skin disease was favorable seen as an epidemic in Zambia in 1929. Initially, it was thought to be the result of either poisoning or a hypersensitivity to insect bites. Additional cases occurred between 1943 and 1945 in Botswana, Zimbabwe, and the Republic of South Africa. Approximately, 8 million cattle were obtains in a panzootic infection in South Africa in 1949, progressing enormous economic losses. LSD spread throughout Africa between the 1950s and 1980s, affecting cattle in Kenya, Sudan, Tanzania, Somalia, and Cameroon.
In 1989 there was an LSD outbreak in Israel. This outbreak was the first instance of LSD north of the Sahara desert and outside of the African continent.[2] This clear outbreak was thought to be the result of infected Stomoxys calcitrans inhabit carried on wind from Ismailiya in Egypt. During a conditions of 37 days between August and September 1989, fourteen of the seventeen dairy herds in Peduyim manufactured infected with LSD.[7] All of the cattle as well as dinky flocks of sheep and goats in the village were slaughtered.[7]
Throughout the past decade, LSD occurrences have been reported in Middle Eastern, European, and west Asian regions.[2]
Bangladesh [ edit ]
LSD was favorable reported to the BangladeshDepartment of Livestock Services in July 2019.[8] Eventually 500,000 head are estimated to have been infected in this outbreak.[8] The Married NationsFood and Agriculture Organization has recommended mass vaccination.[8] As a remnant of the introduction of fall armyworm and this cattle plague within a few months of each latest, the FAO, the World Food Programme, Bangladesh Government officials, and others agreed to begin improving Bangladesh's livestock disease surveillance and emergency response capabilities.[8]
Pakistan [ edit ]
In July 2022, the outbreak spread in 14 out of 33 districts of Gujarat position of India. By 25 July, more than 37000 cases and 1000 deaths in cattle were reported.[9]
As of 1 August 2022, more than 25,000 cases were reported in Rajasthan in which more than 1200 bovines died.[10]
References [ edit ]
- ^ Şevik, Murat; Avci, Oğuzhan; Doğan, Müge; İnce, Ömer Barış (2016). "Serum Biochemistry of Lumpy Skin Disease Virus-Infected Cattle". BioMed Research International. 2016: 6257984. doi:10.1155/2016/6257984. ISSN 2314-6133. PMC 4880690. PMID 27294125.
- ^ abcdefghijkl http://www.oie.int/fileadmin/Home/eng/Health_standards/tahm/2.04.13_LSD.pdf [bare URL PDF]
- ^ abcdefghijklmnop Coetzer, J.A.W. (2004). Infectious Diseases of Livestock. Cape Town: Oxford University Press. pp. 1268–1276.
- ^ abcdefghijklm Tulman, E. R.; Afonso, C. L.; Lu, Z.; Zsak, L.; Kutish, G. F.; Rock, D. L. (2001-08-01). "Genome of Lumpy Skin Disease Virus". Journal of Virology. 75 (15): 7122–7130. doi:10.1128/JVI.75.15.7122-7130.2001. ISSN 0022-538X. PMC 114441. PMID 11435593.
- ^ Carter, G.R.; Wise, D.J. (2006). "Poxviridae". A Concise Review of Veterinary Virology. Retrieved 2006-07-25.
- ^ Ibelli, A. M. G.; Ribeiro, A. R. B.; Giglioti, R.; Regitano, L. C. A.; Alencar, M. M.; Chagas, A. C. S.; Paço, A. L.; Oliveira, H. N.; Duarte, J. M. S. (2012-05-25). "Resistance of cattle of various genetic groups to the tick Rhipicephalus microplus and the relationship with coat traits". Veterinary Parasitology. 186 (3): 425–430. doi:10.1016/j.vetpar.2011.11.019. hdl:11449/4968. PMID 22115946.
- ^ abc Yeruham, I; Nir, O; Braverman, Y; Davidson, M; Grinstein, H; Haymovitch, M; Zamir, O (July 22, 1995). "Spread of Lumpy Skin Disease in Israeli Dairy Herds". The Veterinary Record. 137–4 (4): 91–93. doi:10.1136/vr.137.4.91. PMID 8533249. S2CID 23409535.
- ^ abcd "Co-ordinating a response to Fall Armyworm and Lumpy Skin Disease in Bangladesh". United NationsFood and Agriculture Organization in Bangladesh. Retrieved 2021-02-12.
- ^ "Gujarat: Lumpy skin disease spreads in 14 districts, claims 1000 livestock". The Indian Express. 2022-07-24. Retrieved 2022-07-25.
- ^ "Rajasthan: 25,000 bovines infected by contagious lumpy skin disease, over 1,200 dead". The Indian Express. 30 July 2022. Retrieved 2 August 2022.
External links [ edit ]
Now you are being an article with the title Lumpy skin disease - Wikipedia.
Hopefully this article will be useful for you.
Please share if you find this article has beneficial.
Source: Click here